22nd Century Group, Inc. (NYSE MKT:XXII), a plant biotechnology company that is a leader in tobacco harm reduction, announced today that the Company will present at the upcoming 28th Annual ROTH Investor Conference. The conference will be held on March 13-16, 2016 at The Ritz-Carlton, 1 Ritz-Carlton Drive, Dana Point, California.

Gregg M. Gellman, Director of Business Development & Regulatory Affairs of 22nd Century Group, will deliver a formal presentation including business overview, highlights, and updates on the Company. In addition, Mr. Gellman will be available for one-on-one meetings at the conference. To arrange a meeting with 22nd Century, please contact Andrew Haag atxxii@irthcommunications.com or 1-866-976-4784.

About 22nd Century Group, Inc.

22nd Century is a plant biotechnology company focused on technology which allows it to increase or decrease the level of nicotine in tobacco plants and the level of cannabinoids in cannabis plants through genetic engineering and plant breeding. The Company’s primary mission is to reduce the harm caused by smoking. 22nd Century currently owns or exclusively controls more than 200 issued patents and more than 50 pending patent applications around the world. The Company’s strong IP position led to a licensing agreement with British American Tobacco (“BAT”), the world’s second largest tobacco company. Visit www.xxiicentury.com andwww.magiccigarettes.com for more information.

About 28th Annual ROTH Conference

The ROTH conference is one of the largest of its kind in the U.S. With over 500 participating companies and over 3,000 attendees, the conference will feature presentations from hundreds of public and private companies in a variety of sectors including: Business Services, Cleantech & Solar, Consumer, Biotechnology, Healthcare, Resources, Retail & E-Commerce and Technology & Media. The conference includes company presentations, Q&A sessions, expert panels and thousands of management one-on-one and small group meetings.

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