Tetra Bio-Pharma Inc. (TBPMF) Provides PPP003 Inflammatory Cytokine Reduction Drug Program

Dr. Chamberland further commented, “Tetra has submitted a grant application to the Strategic Innovation Fund announced two weeks ago by Prime Minister Justin Trudeau. We hope that this committee will recognize the extensive research performed by the PANAG founders at Dalhousie University. This level of in-depth research, which has been published in over ten peer reviewed scientific journals, is exceptional for a biotechnology company, especially when it is recognized by the international scientific and medical community.

About PPP003 in COVID-19 Infected Patients

Severe coronavirus disease 2019 (COVID-19) represents viral pneumonia from SARS-CoV-2 leading to acute respiratory distress syndrome (ARDS) with lung inflammation and damage (alveolar damage). These patients have exaggerated inflammatory and immune responses, with enhanced release of pro-inflammatory molecules – referred to as “cytokine storm”. Essentially the immune system is in overdrive/out of control which can lead to further complications including blood clots and scarring or fibrosis. ARDS develops in 42% of patients presenting with COVID-19 pneumonia, and 61-81% of those requiring ICU care.

The “cytokine storm” in this context is easier to consider as a symptom than a cause, and is triggered by infection (viral e.g. SARS-CoV-2 or bacterial e.g. sepsis). As with other potential Covid-19 therapies being considered, PPP003 will target symptoms rather than the origin of the disease to reduce the extreme outcomes of a “cytokine storm” in patients with ARDS.

In sepsis, ARDS represents the severe end of lung dysfunction which can result from systemic inflammatory responses or from infection in the lungs, themselves. This cytokine-mediated inflammatory response is very similar to what is seen in viral infections like influenza or Covid-19. PPP003 was shown in experimental models to decrease pro-inflammatory cytokines (IL-6 and TNF) in acute lung injury models similar to what occurs in sepsis . PPP003, a specific CB2 agonist, also stops the efflux of inflammatory cytokines like TNF and IL-1ß in acute lung injury induced in other experimental models.

About Tetra Bio-Pharma

Tetra Bio-Pharma (TSX-V:TBP) (TBPMF) is a biopharmaceutical leader in cannabinoid-based drug discovery and development with a Health Canada approved, and FDA reviewed and approved, clinical program aimed at bringing novel prescription drugs and treatments to patients and their healthcare providers. The Company has several subsidiaries engaged in the development of an advanced and growing pipeline of Bio Pharmaceuticals, Natural Health and Veterinary Products containing cannabis and other medicinal plant-based elements. With patients at the core of what we do, Tetra Bio-Pharma is focused on providing rigorous scientific validation and safety data required for inclusion into the existing bio pharma industry by regulators, physicians and insurance companies.

For more information visit: www.tetrabiopharma.com

Source: Tetra Bio-Pharma

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Forward-looking statements

Some statements in this release may contain forward-looking information. All statements, other than of historical fact, that address activities, events or developments that the Company believes, expects or anticipates will or may occur in the future (including, without limitation, statements regarding potential acquisitions and financings) are forward-looking statements. Forward-looking statements are generally identifiable by use of the words “may”, “will”, “should”, “continue”, “expect”, “anticipate”, “estimate”, “believe”, “intend”, “plan” or “project” or the negative of these words or other variations on these words or comparable terminology. Forward-looking statements are subject to a number of risks and uncertainties, many of which are beyond the Company’s ability to control or predict, that may cause the actual results of the Company to differ materially from those discussed in the forward-looking statements. Factors that could cause actual results or events to differ materially from current expectations include, among other things, without limitation, the inability of the Company to obtain sufficient financing to execute the Company’s business plan; competition; regulation and anticipated and unanticipated costs and delays, the success of the Company’s research and development strategies, including the success of this product or any other product, the applicability of the discoveries made therein, the successful and timely completion and uncertainties related to the regulatory process, the timing of clinical trials, the timing and outcomes of regulatory or intellectual property decisions and other risks disclosed in the Company’s public disclosure record on file with the relevant securities regulatory authorities. Although the Company has attempted to identify important factors that could cause actual results or events to differ materially from those described in forward-looking statements, there may be other factors that cause results or events not to be as anticipated, estimated or intended. Readers should not place undue reliance on forward-looking statements. The forward-looking statements included in this news release are made as of the date of this news release and the Company does not undertake an obligation to publicly update such forward-looking statements to reflect new information, subsequent events or otherwise unless required by applicable securities legislation.

For further information, please contact Tetra Bio-Pharma Inc.:

Investor Contact:

Alpha Bronze, LLC
Mr. Pascal Nigen
Phone: + 1 (646) 255-0433
tetra@alphabronze.net

Public Relations:

Energi PR
Ms. Carol Levine
Phone: + 1 (514) 288-8500 ext. 226
carol.levine@energipr.com

SOURCE: Tetra Bio-Pharma