$IMLFF Announces Progress in Orofacial Pain Program

Following the recently completed in silico work using InMed’s proprietary “IDP” platform to identify cannabinoid compounds for its orofacial pain program (see News Release dated March 18, 2015), InMed completed validation of the preclinical pain model using nerve growth factor (NGF) induced pain in rats. Preliminary data indicates that primary afferent neurons innervating the masseter muscles of female rats expressed CB1 and CB2 and these expressions were found in satellite glial cells in the trigeminal ganglion.

Dr. Sazzad Hossain, Chief Scientific Officer of Inmed Pharmaceuticals stated “these results suggest that in pain conditions where the level of NGF is elevated, pain is mediated, in part, by the reduction of the inhibitory input by the endo-cannabinoid system in the periphery. Peripheral application of cannabinoids may counter this effect and provide analgesic relief”.

InMed is currently conducting further preclinical works using selected cannabinoid compound compounds to develop a new therapy for orofacial pain.

About InMed

InMed is a clinical stage biopharmaceutical company that specializes in developing novel therapies through the research and development into the extensive pharmacology of cannabinoids coupled with innovative drug delivery systems. InMed’s proprietary platform technology, product pipeline and accelerated development pathways are the fundamental value drivers of the company.

For more information, visit www.inmedpharma.com.

ON BEHALF OF THE BOARD

InMed Pharmaceuticals Inc.

Craig Schneider, President and Chief Executive Officer

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