We live by converting the energy in foods, made up of carbohydrates, lipids, various proteins, enzymes, and other vital nutrients, into energy that can be used by the body.  These nutrients must either be produced by the body itself or consumed in the food we eat or supplements we take. Our body is remarkably adaptive to be able to not only survive but to thrive off a variety of food sources. Simply look to the variety of foods in the local market or the variety of cuisine around the world and you will see the multitude of ways people get the nutrition and energy that they need to live.

Our ability to adapt is due in part to the fact that our cells evolve to become  tissues, organs and physiological systems involved in energy metabolism and digestion. One only needs to think about the complexity of all these organs and systems to realize how important it is to have good communication between different cell types in response to changes in the environment.


The ability of cells to communicate is a result of the endocannabinoids, which are fatty-acid amides that are produced in response to changes in the environment. These highly specialized cells, which regulate energy metabolism in the body, have special energy requirements. Closely modulating the utilization of energy by these specialized cells is critical for promoting healthy energy metabolism. Without control, these cells can produce too many by-products of metabolism, harming the system. This happens thanks to metabolic feedback loops that correct for a buildup of metabolic by-products by shifting our metabolism from gluconeogenesis, the generation of glucose from glycogen stores, to ketogenesis, the breakdown of fats to form ketones.

Glycolysis is the primary mechanism our body uses to convert energy from carbohydrates, or sugars, into ATP which is the energy currency used by all our cells. Screen Shot 2016-03-28 at 12.47.17 PM
Fatty acid metabolism is, a much slower process, requires oxygen, and produces more by-products of metabolism compared to glycolysis. Optimal production of energy, known as cellular metabolism, requires a balance between carbohydrate and fat metabolism. This is where natural cannabinoids play an important role. The endocannabinoid system (ECS) has evolved to help modulate the regulation of cellular metabolism and subsequent energy production through the two primary cannabinoid receptors, CB1 and CB2.

The CB1 receptor is primarily involved in regulating glycolysis, sugar metabolism, while the CB2 receptor is mostly involved with controlling fat metabolism. The ECS creates a system of checks and balances that exist between the processes responsible for metabolizing sugars and those involved in metabolizing fats.

Our metabolism affects more than just our weight, it also affects our overall health and vitality. By using products like Randy’s Remedy, Powered by Cannaka, people are able to better support a healthy metabolism using natural cannabinoids and improve energy metabolism. Cannabinoid receptors are active at the outside as well as within the cells where they control the rate of cellular respiration in the mitochondria, known as the cell’s power plant. By modulating the ECS with natural cannabinoids you can affect the rate at which cells consume oxygen and the rate at which mitochondria produce energy.


Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the cannabinoid system performs different tasks, but the goal is always to maintain homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment. Cannabinoids  stimulate our bodies’ ability to self-heal and help our improve the quality of life. All this suggests that our metabolism and even the rate at which we age is at some level controlled by the ECS and can be modulated with the use of natural cannabinoids.

Authored by: Tyler Strause

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