$PMCB Scientific Advisory Board Chairman Publishes Review Article

The review article highlights the lack of recommendations for the macroscopic examination, tissue sampling and microscopic assessment of pancreatic cancer as well as the grading of tumor regression and assessment of residual tumor tissue, in contrast to those seen with other cancers. All of these factors are important parameters in assessing treatment outcome in clinical trials of patients with pancreatic cancer undergoing neoadjuvant therapy (used to shrink a tumor prior to additional treatment such as surgery) and the divergence of these matters among pancreatic cancer clinical trials makes interpretation of trial results and comparisons among trials quite difficult. Accordingly, the authors of the review article have made interim suggestions for dealing with these criteria and call for an international consensus on dealing with these critical parameters.

Kenneth L. Waggoner, CEO of PharmaCyte Biotech, stated, “Prof. Lohr and his colleagues have highlighted a major deficit in the diagnosis, treatment and the evaluation of treatment success in pancreatic cancer in this important publication. Not only is this relevant for the future treatment of pancreatic cancer, but it is also a key for measuring success in clinical trials in comparison to other treatments. All of the factors discussed in this review article should be considered in conducting trials in patients with pancreatic cancer which, of course, includes our upcoming Phase 2b clinical trial.”

In commenting on the review article, Dr. Lohr emphasized, “Despite the fact that pathology provides key outcome parameters in terms of tumor regression and completeness of surgical resection following neoadjuvant treatment, worldwide there are inconsistencies in various aspects of pathology examination such as specimen dissection, tissue sampling, evaluation of tumor regression and margin status assessment which can confound diagnosis as well as evaluation of treatment success in pancreatic cancer. We are calling for international consensus on these critical parameters since we believe that this is of utmost importance as we move towards newer treatments for this devastating disease.”

About PharmaCyte Biotech

PharmaCyte Biotech is a clinical stage biotechnology company focused on developing and preparing to commercialize treatments for cancer and diabetes based upon a proprietary cellulose-based live cell encapsulation technology known as Cell-in-a-Box^(R). This unique and patented technology will be used as a platform upon which treatments for several types of cancer, including advanced, inoperable pancreatic cancer, and diabetes are being built. PharmaCyte Biotech’s treatment for pancreatic cancer involves low doses of the well-known anticancer prodrug ifosfamide, together with encapsulated live cells, which convert ifosfamide into its active or “cancer-killing” form. These capsules are placed as close to the cancerous tumor as possible to enable the delivery of the highest levels of the cancer-killing drug at the source of the cancer. This “targeted chemotherapy” has proven remarkably effective in past clinical trials. PharmaCyte Biotech is also working towards improving the quality of life for patients with advanced pancreatic cancer and on treatments for other types of solid cancerous tumors. In addition, PharmaCyte Biotech is developing treatments for cancer based upon chemical constituents of the Cannabis plant, known as cannabinoids. In doing so, PharmaCyte Biotech is examining ways to exploit the benefits of Cell-in-a-Box^(R) technology in optimizing the anticancer effectiveness of cannabinoids, while minimizing or outright eliminating the debilitating side effects usually associated with cancer treatments. This provides PharmaCyte Biotech the rare opportunity to develop “green” approaches to fighting deadly diseases, such as cancer of the pancreas, brain and breast, which affect hundreds of thousands of individuals worldwide every year.

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Investor Relations Contacts:
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Blueprint Life Science Group
Telephone: 415.375.3340 Ext. 103
jjones@bplifescience.com