Tags Posts tagged with "Nemus Bioscience"

Nemus Bioscience

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The emergence of the cannabis industry has led to the creation of sub-industries within it and this has created numerous opportunities for investors.

One sub-industry we find to be very attractive is biotech and this is due to the potential development of numerous billion dollar products.

The potential medical benefits of cannabis can no longer be ignored as agencies like the National Cancer Institute (NCI) continue to recognize its potential. In 2015, the NCI updated its website to include various studies that reveal how cannabis may inhibit tumor growth by killing cells.

Betting on Biotech

Although the biotech industry offers a lot of opportunity, it presents even more risk. When we look at biotech investment opportunities, we look for companies that possess a competitive or unique advantage over their peers.

Last week, one of the biotech companies we have been monitoring closely, Nemus Bioscience (NMUS), announced that it will be advancing the development of a human-dosage suppository formulation of NB1222 with Catalent Pharma Solutions. The product candidate is the proprietary prodrug of tetrahydrocannabinol (THC).

NB1222 has been synthetically manufactured and is being developed to treat and manage chemotherapy-induced nausea and vomiting (CINV). Nemus also plans on advancing this prodrug into formulation activity for the glaucoma indication using its NB1111 candidate molecule.

Today, Nemus signed a development agreement with United Kingdom-based Nanomerics to develop a topical ocular formulation of tetrahydrocannabinol-valine-hemisuccinate (THCVHS), the prodrug of THC, the active component of Nemus drug candidate NB1111 being developed for glaucoma.

The goal of the agreement is to conduct initial studies assessing the preparation of clinical-grade eye drops using the patented Molecular Envelope Technology (MET) developed by Nanomerics.

According to the agreement, work will commence on a future date determined by Nemus. The date is expected to be related with its development plans and corporate objectives.

Nemus Bioscience CEO Brian Murphy said, “Should we find success in formulating NB1111 using Nanomerics’ MET, we could also examine its application using our proprietary Nemus ophthalmic analogue of CBD (NB2222). Our company objective is to establish strategic partnerships utilizing a diverse cannabinoid-based ocular platform to address multiple types of eye disease.”

A Stock to Watch

Nemus Bioscience is an interesting company to watch due to its valuation, product pipeline, and its strategic partnership with the University of Mississippi. The university has been the sole provider of cannabis for medical research through a partnership with the National Institutes of Health since 1968.

We are favorable on this update as it shows further execution by Nemus. The company’s strategic relationship with Federal agencies makes it an attractive opportunity for investors and a stock to watch.

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Currently, 40 states have passed laws that allow for the use of some form of medical marijuana. Even though marijuana clearly has medical benefits, it remains a Schedule I substance alongside heroin, LSD, ecstasy, and bath salts under the Controlled Substances Act (CSA). According to the United States Drug Enforcement Agency, Schedule I substances have the following characteristics:

  • The substance has a high potential for abuse.
  • The substance has no currently accepted medical treatment use in the U.S.
  • There is a lack of accepted safety for use of the substance under medical supervision.

In late June, the White House took a major step forward to support cannabis research by eliminating the Public Health Service review requirement. Now, the Office of National Drug Control Policy (ONDCP) will help facilitate medical marijuana research.

Marijuana advocates have said that the federal government’s strict rules on marijuana research have prevented researchers from performing necessary studies in the United States. These strict polices have caused the United States to experience a “brain drain” with regard to scientists interested in learning about the medical benefits associated with marijuana.

Dr. Alan Shackelford moved to Israel after seeing U.S. drug laws block clinical studies into promising applications that treat illnesses which conventional medicine cannot treat. Dr. Shackelford is a Harvard-trained physician who was Charlotte Figi’s doctor.

Shackelford said, “I went to Israel because I was frustrated. Israel is the one place in the world that combines the scientific expertise, world-class universities and scientists. It’s so exciting.”

In a study published by the National Bureau of Economic Research, researchers were able to determine that the states with medical marijuana dispensaries experience a decrease in opioid addictions and overdose deaths compared to states that do not.

Five overlooked benefits of marijuana

Five overlooked benefits of marijuana include its potential to treat the following debilitating and deadly diseases:

1) Cancer

Cannabinoids, the active components of marijuana, inhibit tumor growth in laboratory animals and also kill cancer cells. In April 2015, the National Institute on Drug Abuse (NIDA) reported that marijuana can kill certain cancer cells. The monthly publication was revised to say the following:

“Recent animal studies have shown that marijuana can kill certain cancer cells and reduce the size of others. Evidence from one animal study suggests that extracts from whole-plant marijuana can shrink one of the most serious types of brain tumors. Research in mice showed that these extracts, when used with radiation, increased the cancer-killing effects of the radiation.”

2) Fibromyalgia

Zynerba Pharmaceuticals (ZYNE: NASDAQ) is a specialty pharmaceutical company focused on developing and commercializing synthetic cannabinoid therapeutics formulated for transdermal delivery. Zynerba is developing two therapeutic candidates based on proprietary transdermal technologies.

The company’s THC Pro-Drug Patch is a pro-drug of THC that enables transdermal delivery via a patch. Zynerba is studying ZYN001 in patients with fibromyalgia and peripheral neuropathic pain.

3) Epilepsy

In mid-April, the American Academy of Neurology (AAN) issued a statement saying GW Pharmaceutical’s (GWPH: NASDAQ) Epidiolex product, “may show promise” in the treatment of severe epilepsy in children.

The AAN provided the results of a study of 213 people (median age of 11) who suffered from severe epilepsy and did not respond to other treatments. For the 137 people who completed the 12-week study, the number of seizures decreased by an average of 54%.

Among the 23 people with Dravet syndrome who finished the study, the number of convulsive seizures had gone down by 53%. For the 11 people with Lennox-Gastaut syndrome who finished the study, there was a 55% reduction in the number of atonic seizures, which cause a sudden loss of muscle tone. A total of 12 people, or 6%, stopped taking the drug due to side effects.

4) Glaucoma

In December, Nemus Bioscience Inc. (NMUS) reported that Dr. Soumyajit Majumdar, an Associate Professor of Pharmaceutics at the University of Mississippi, presented data at the American Association of Pharmaceutical Scientists (AAPS) that showed that a pro-drug formulation of delta-9-tetrahydrocannabinol (THC) significantly lowered intra-ocular pressure (IOP) in an open-angle rabbit glaucoma model.

The rabbits that received the THC pro-drug saw a greater percentage drop in IOP when compared to timolol, and an even greater percentage drop when compared to pilocarpine. The THC pro-drug resulted in an IOP lowering effect of 45%-50%.

5)Multiple Sclerosis

Marijuana can be used as a treatment for multiple sclerosis. GW Pharmaceutical’s (GWPH: INSY) Sativex product is sold as a treatment for multiple sclerosis and is derived from cannabis. Sativex is sold in 27 countries and it is currently in Stage 3 FDA testing (results expected late 2015/early 2016).

But it still remains a Schedule I substance

The benefits of marijuana can no longer be ignored. The recent findings, NIDA’s admission, company developments, and the opinion of Dr. Sanjay Gupta and of the United States Surgeon General should be enough to reschedule marijuana and promote research into it.

– See more at: https://technical420.com/cannabis-article/why-schedule-i-label-make-no-sense#sthash.4oYObqKn.tdaE7ZMT.dpuf

 

Authored by: Micheal Berger

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