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Oxis Adds New Patients in Phase 1/Phase 2 Clinical Trial of Key Cancer Drug OXS-1550

 Oxis International Inc. (OTC:OXIS and OXI.PA), a biotechnology company focused on immunotherapies for the treatment of cancer, announced today that it has enrolled six new patients in a Phase 1/Phase 2 trial of its most promising cancer drug, OXS-1550.

The FDA-approved clinical trial is being conducted at the University of Minnesota’s Masonic Cancer Center under the watch of Dr. Daniel Vallera, a research scientist who developed the drug and is a member of the Scientific Advisory Board of Oxis’ wholly owned subsidiary, Oxis Biotech Inc.

The six new patients bring to 32 the number of patients who have participated in the clinical trial.

All the new patients are given an approved increased dosage of OXS-1550. It was the increased dosage that was credited with the complete remission of patient Cynthia Cattell.

Ms. Cattell said all other treatments for her aggressive B-cell lymphoma had failed – until she was treated with OXS-1550.

She was the first patient to received four infusions of the drug over an eight-day span in the Phase 1 clinical trial. One month later, a doctor overseeing the clinical trial found a 75 percent reduction in the size of Cattell’s tumor. She’s is now cancer free for more than one year.

What sets OXS-1550 (DT2219ARL) apart is that it is designed to target cancer cells and destroy them, while leaving healthy cells alone. When OXS-1550 binds to cancer cells, the cancer cells internalize the drug and are killed. Vallera said. As a result, the treatment has lower occurrences of side effects than more common cancer treatments.

“We believe OXS-1550 to be a powerful alternative to existing chemotherapies, since many patients fail chemotherapy or reach the toxic limits of their therapy,” Vallera said.

“OXS-1550 is designed to be an off-the-shelf drug that is safe and more cost-effective than CAR-T technologies (JUNO and KITE) and much less invasive on the patient,” said Anthony Cataldo, Chairman and Chief Executive Officer of Oxis. “It will serve a much larger audience at a significantly reduced cost.”

“We are extremely encouraged about the potential of OXS-1550,” Mr. Cataldo said.

ABOUT OXIS INTERNATIONAL, INC.

Oxis International, Inc., through a wholly owned subsidiary, Oxis Biotech, Inc., develops innovative drugs focused on the treatment of cancer and other unmet medical needs. Oxis’ lead drug candidate, OXS-1550 (DT2219ARL) is a novel bispecific scFv recombinant fusion protein-drug conjugate composed of the variable regions of the heavy and light chains of anti-CD19 and anti-CD22 antibodies and a modified form of diphtheria toxin as its cytotoxic drug payload. OXS-1550 simultaneously targets cancer cells expressing the CD19 receptor or CD22 receptor or both receptors. When OXS-1550 binds to cancer cells, the cancer cells internalize the drug and are killed due to the action of drug’s cytotoxic payload. OXS-1550 has demonstrated success in early human clinical trials in patients with relapsed/refractory B-cell lymphoma or leukemia. OXS-4235 is a small molecule therapeutic candidate targeting the treatment of multiple myeloma and associated osteolytic lesions. In in vitro and in vivo models of multiple myeloma and osteoporosis, OXS-4235 demonstrated the ability to kill multiple myeloma cells, and decrease osteolytic lesions in bone. OXIS’ lead drug candidate, OXS-2175, is a small molecule therapeutic candidate targeting the treatment of triple-negative breast cancer (TNBC). In in vitro and in vivo models of TNBC, OXS-2175 demonstrated the ability to inhibit metastasis.

FORWARD LOOKING STATEMENTS:

Except for historical information contained herein, the statements in this release are forward-looking and made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements are inherently unreliable and actual results may differ materially. Examples of forward-looking statements in this news release include statements regarding the payment of dividends, marketing and distribution plans, development activities and anticipated operating results. Factors which could cause actual results to differ materially from these forward-looking statements include such factors as the Company’s ability to accomplish its business initiatives, significant fluctuations in marketing expenses and ability to achieve and expand significant levels of revenues, or recognize net income, from the sale of its products and services, as well as the introduction of competing products, or management’s ability to attract and maintain qualified personnel necessary for the development and commercialization of its planned products, and other information that may be detailed from time to time in the Company’s filings with the United States Securities and Exchange Commission. The Company undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

Disclaimer:An affiliate of MAPH, owners of MarijuanaStocks.com, MIDAM VENTURES, LLC was paid an advertising fee of $477,000 cash & ZERO Restricted Common shares by OXIS for visual sponsorship and for visual placement of OXIS within written materials. FOR A DURATION OF 6 MONTHS Beginning 6/14/2016. & ending 11/14/2016

Company website: www.oxis.com

Media Contact:
Stuart Pfeifer
Sitrick & Company
(310) 788-2850

SOURCE: Oxis International Inc.


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